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Grape seed extract standardized to contain 95% proanthocyanidins is a concentrated form of the bioactive compounds found in grape seeds. Proanthocyanidins, also known as oligomeric proanthocyanidins (OPCs), are powerful antioxidants that are believed to be the primary active ingredients in grape seed extract.
Here’s what you can expect from grape seed extract with 95% proanthocyanidins:

Antioxidant Properties: Proanthocyanidins are potent antioxidants that help neutralize harmful free radicals in the body, thereby reducing oxidative stress and the risk of chronic diseases such as heart disease, cancer, and neurodegenerative disorders.

Heart Health: Grape seed extract may help support cardiovascular health by promoting healthy blood pressure, improving blood flow, and reducing inflammation and oxidative damage to blood vessels.

Skin Health: Proanthocyanidins in grape seed extract have been studied for their potential to support skin health by protecting against UV radiation damage, reducing the signs of aging, and promoting collagen synthesis.

Brain Health: Some research suggests that grape seed extract may have neuroprotective effects and could help improve cognitive function and memory.

Anti-inflammatory Effects: Proanthocyanidins have anti-inflammatory properties, which may help reduce inflammation in the body and alleviate symptoms associated with inflammatory conditions such as arthritis.
When selecting a grape seed extract supplement with 95% proanthocyanidins, it’s important to choose a reputable brand that uses high-quality ingredients and has undergone third-party testing for potency and purity.

As with any supplement, it’s advisable to consult with a healthcare professional before starting, especially if you have any underlying health conditions or are taking medications. They can provide personalized guidance on dosage and potential interactions.

Proanthocyanidins: GSE is one of the best-known sources of proanthocyanidins. These compounds contribute to its health benefits.

Blood Pressure Regulation:
Studies suggest that GSE can reduce blood pressure. For instance:
A review of 16 studies found that taking 100–2,000 mg of GSE daily significantly reduced systolic and diastolic

blood pressure.
Young to middle-aged individuals with obesity or metabolic disorders showed the greatest improvements.
Lower doses (100–800 mg daily) over 8–16 weeks were more effective than single higher doses1.
Another study demonstrated that 300 mg of GSE daily lowered systolic blood pressure by 5.6% and diastolic blood pressure by 4.7% after 6 weeks.

Improved Blood Flow:

GSE may enhance blood flow:
In postmenopausal women, 400 mg of GSE had blood-thinning effects, potentially reducing the risk of blood clots. Leg swelling and edema were reduced by 70% in healthy young women